The Toxic Substances Control Act 1976 (TSCA) is an important standard in US American chemical regulation which the US American environmental authority, known as the Environmental Protection Agency (EPA), is charged with implementing.

The EPA is responsible for maintaining an inventory of all chemical substances produced or processed in the United States or imported into the United States.

On 6 January 2021, the US-American environmental authority (EPA) published new regulations under TSCA Section 6(h) in order to restrict the import and use of five persistent, bioaccumulative toxic (PBT) chemicals.